The New Science of Chronic Disease
A series for clinicians by William H. Bestermann Jr., MD: why high blood pressure, diabetes and heart failure grow from the same biology, and why treating early with inexpensive generics preserves organs without financial harm. Start with the Introduction.
A clinical education series for physicians and care teams, separate from our employer articles.
Take the series as a course and get PHCC certified
Free. Designed and approved by PHCC. Not CME credit or board certification.
Every lesson below stays free and open — read any of them, in any order, without signing up for anything. If you would rather work through it as a course, the certification track takes you from the Introduction to the Clinical Masterclass in sequence, with a short assessment after each lesson.
- 9 lessons, in order
- 5 questions each
- 80% to pass
- Unlimited retakes
- PDF certificate of completion
The Biology of Chronic Disease
Why high blood pressure, diabetes and heart failure grow from the same biology, and what turns it on.
Introduction to Clinician Education
Why the series exists and how to use it.
Read on Substack
The Evolutionary Engine that Won’t Turn Off
How growth signals that once helped us survive now drive chronic disease.
Read on Substack
The Upstream Spark: Belly Fat, Cigarette Smoke, and the Hijacked Growth Switch
What switches that engine on.
Read on Substack
The Dual-Rheostat: mTOR vs. AMPK and the Choice Between Decay and Repair
The balance inside the cell between decay and repair.
Read on SubstackFrom Science to Protocol
How the biology becomes prevention and a primary care protocol built on inexpensive generics.
The Oncogene Highway in Chronic Disease: Why OMT Is Chemoprevention in Plain Sight
Why Optimal Medical Therapy also works as chemoprevention.
Read on Substack
The 5-to-7 Pillar Generic Shield: Translating Systems Biology into Primary Care Protocols
Turning the science into a primary care protocol built on inexpensive generics.
Read on SubstackThe Evidence and Acting Early
What the trials proved, a health system that put it into practice, and why the earliest stage matters most.
Clinical Masterclass
Clinical Masterclass: Preserving Organs without Incurring Financial Harm
The whole approach in one place: the biology, the generic protocol and the evidence, brought together for practice.
Read on SubstackFor use in practice
The Stages of Heart Failure Criteria
The changes of heart failure begin decades before symptoms. These are the criteria for finding them early.
Open the criteriaWant a record that you have done this?
The certification track covers the same nine lessons, unlocking one at a time, with five questions after each. Pass the Clinical Masterclass capstone and you get a PDF certificate of completion designed and approved by Performance Health Collaborative.
Sign up for the certification